Influence of age on arterial stiffness responses following a short period of sitting in healthy males

Background: Age-related increases in arterial stiffness including carotid-femoral pulse wave velocity (cf-PWV), aortic reflection via augmentation index (AIx) and magnitude (RM) have been associated with future cardiovascular event risk. Chronic or prolonged inactivity has reported to exacerbate the age-related stiffness. However, little is known about impact of a short, period on age potentially an influencing factor. The aim this study was examine effect acute, responses following short sitting healthy males. Methods: Twenty-two young (27.1±7.3 yrs, 177.4±5.4 cm, 82.2±10.2 kg, 26.1±3.1 kg.m-2) twenty-two older (68.8±5.3 174.6±7.6 77.7±7.0 25.6±3.0 males volunteered. Supine, resting measures cf-PWV, AIx corrected heart rate 75 (AIx75) RM were obtained prior (baseline), 20-, 40- 60-minutes (24-30 minutes). Heart (HR), systolic (SBP), diastolic (DBP) mean (MAP) blood pressure recorded throughout period. Significant (p<0.05) differences over time between groups examined by 2-way ANOVA post-hoc, pairwise comparisons Bonferroni correction. Results: During sitting, lower HR (53.9±8.0 vs. 64.6±7.7 bpm, p<0.001) greater peripheral SBP (131.2±13.1 118.8±9.6 mmHg, p<0.001), DBP (79.9±8.7 74.7±6.4 p=0.027) MAP (97.0±9.2 89.4±7.0 p=0.003) observed compared group. group exhibited significantly cf-PWV (9.0±1.4 7.3±0.9 m.s-1, AIx75 (12.6±9.2 4.0±14.0 %, p=0.011) (73.6±14.0 59.0±12.4 (48.9±6.4 55.0±7.7 p=0.002) Compared baseline, increased at after change being similar (p=0.792). In contrast, decreased (p>0.05). Discussion: A resulted significant increase central (cf-PWV) concurrent decrease (AIx75 RM) these unaffected current results extend previous work that even for period, may progressively contribute changes "My co-authors I acknowledge we no conflict interest relevance submission abstract."